Sentieon Genomics software is a set of software tools that perform analysis of genomic data obtained from DNA sequencing.The Sentieon® Genomics software enables rapid and accurate analysis of next-generation sequence data. The Sentieon® DNAseq pipelines enable germline variant calling on hundreds of thousands of samples simultaneously. The Sentieon® TNseq pipelines enable accurate calling of somatic variants in paired tumor-normal samples or in an unpaired tumor samples. The Sentieon® Genomics software produces more accurate results than other tools on third-party benchmarks with results obtained in one tenth the time of comparable pipelines.
Release 202503
| Type | Description |
|---|---|
| Feature | Added support for hybrid short and long-read variant calling. |
| Feature | Added support for reading and writing CRAM version 3.1 files. |
| Feature | Added support in GVCFtyper algorithm for joint calling DNAscope GVCFs from long reads pipeline. |
| Feature | Added support in TNscope algorithm to output FAD, F1R2, and F2R1 annotations. |
| Feature | Added option in GCBias and AlignmentStat algorithms to match with Picard IS_BISULFITE_SEQUENCED option. |
| Feature | Reduced memory utilization in HsMetricAlgo algorithm. |
| Bug-fix | Solved issue in driver where minor inconsistencies in alignment @SQ records can cause an error. |
| Bug-fix | Solved issue in consensus Dedup where paired consensus reads may not have matching read names. |
| Bug-fix | Solved issue in LongReadSV algorithm that could cause a crash under rare circumstances. |
| Bug-fix | Solved issue in DNAscope and Haplotyper that could cause an assertion when using the –bam_output option. |
| Bug-fix | Solved issue in consensus Dedup that would cause the job to hang when –metrics is turned on. |
| Bug-fix | Solved issue in TNhaplotyper2 in given mode that may produce incorrect results. |
| Bug-fix | Solved issue in TNscope that missed low-AF variants at the site of germline homozygous variants. |
| Other | Removed umi consensus from the software package. |
| Other | Removed gnuplot binary from the software package. |
